Anti-AAKR1B1抗体β1肾上腺素能受体（Beta-adrenergic Receptor-1 ）在接受交感神经节后纤维支配的各种器官中存在着与肾上腺素、*起反应的受体，称为肾上腺素能受体。

产品编号 YB-2405R
英文名称 Anti-AAKR1B1抗体
中文名称 醛糖还原酶抗体
别    名 MGC134297; ADR; aldehyde reductase 1; Aldehyde reductase; Aldose reductase; aldr 1; ALDR1; low Km aldose reductase.
Anti-AAKR1B1抗体  
说 明 书 0.2ml  
研究领域 心血管  免疫学  激酶和磷酸酶  糖尿病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AKR1B1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Subunit:
Monomer.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

Similarity:
Belongs to the aldo/keto reductase family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

醛糖还原酶是多元醇通路的关键限速酶,当血糖在正常生理水平时，它并不激活，它对葡萄糖的亲和力较低。在高血糖状况下（如糖尿病），磷酸己糖激酶饱和， 醛糖还原酶激活，促使体内的葡萄糖转化为*。然而，*脱氢酶（sorbitol dehydrogenase，SDH）的活力并未相应地成比例增加，*转化为果糖的效率没有提高,*本身由于极性强不易通过细胞膜，在细胞内会形成蓄积，使细胞膜的通透性发生改变，并使细胞中Na+-K+-ATP酶活性下降，造成肌醇丧失，导致细胞代谢与功能的损害。
因眼睛和神经细胞等组织内醛糖还原酶的含量较高，糖尿病病人体内高血糖的环境使这一通路很容易被打开，造成对相关组织的病理损害，如糖尿病、白内障、神经病变、肾脏病变、视网膜病变、动脉粥样硬化等糖尿病并发症DCC的发生。