Anti-ATP4B抗体的优点在于它是癌症特异性，在癌症组织中高表达。 AMACR亦可用作其他癌症的诊断标志物。对各种癌症细胞进行检查后发现，结肠直肠癌、卵巢癌、乳腺癌、膀胱癌、肺癌、淋巴瘤和黑素瘤都过度表达AMACR，以结肠直肠癌和前列腺癌表达Z高。

产品编号 bYB-2433R
英文名称 Anti-ATP4B抗体
中文名称 氢钾ATP酶通道蛋白抗体
别    名 Gastric H(+)/K(+) ATPase subunit beta; H+K+ ATPase; ATP4B; ATP6B; ATPase H+/K+ exchanging beta polypeptide; ATPase H+/K+ transporting beta polypeptide;Gastric H K ATPase catalytic subunit; Gastric H+/K+ ATPase beta subunit; Gastric hydrogen potassium ATPase; Gastric hydrogen potassium ATPase beta; Hydrogen/potassium exchanging ATPase 4B; Potassium transporting ATPase beta chain; Potassium transporting ATPase subunit beta; Proton pump; Proton pump beta chain; ATP4B_HUMAN.
Anti-ATP4B抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATP4B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Function:
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

Subunit:
Composed of two subunits: alpha (catalytic) and beta.

Subcellular Location:
Cell membrane

Tissue Specificity:
Expressed at highest levels in heart, skeletal

Similarity:
Belongs to the X(+)/potassium ATPases subunit beta family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.