Anti-ADCY1抗体腺苷酸环化酶（adenylate cyclase, AC） 是G蛋白偶联受体家族之一，是膜整合蛋白,它的氨基端和羧基端都朝向细胞质。

产品编号 yb-3681R
英文名称 Anti-ADCY1抗体
中文名称 腺苷酸环化酶1抗体
别    名 3'5' cyclic AMP synthetase; ADCY1; adenyl cyclase; Adenylate cyclase 1; adenylate cyclase type I; ATP pyrophosphate lyase; Brain adenylate cyclase 1; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; ADCY1_HUMAN; Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase. .
Anti-ADCY1抗体   
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  信号转导  转录调节因子  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adenylyl cyclase
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The membrane bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein coupled receptors. Eight human AC isoforms (AC-1 through AC-4) have been identified up to now and genes for at least nine adenylate cyclase (AC-1-AC-9) have been cloned characterized and sequenced. This is a calmodulin-sensitive adenylyl cyclase which may be involved in regulatory processes in the central nervous system. It may play a role in neuronal plasticity, memory acquisition and learning and is expressed predominantly in the brain, retina and adrenal medulla.

Function:
This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Brain, retina and adrenal medulla.

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.

Database links:
UniProtKB/Swiss-Prot: Q08828.2 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

腺苷酸环化酶(adenylate cyclase, AC) 是G蛋白偶联受体家族之一，是膜整合蛋白,它的氨基端和羧基端都朝向细胞质。AC在膜的细胞质面有两个催化结构域,还有两个膜整合区,每个膜整合区分别有6个跨膜的α螺旋。哺乳动物中已发现6个腺苷酸环化酶异构体。由于AC能够将ATP转变成cAMP,引起细胞的信号应答,因此,腺苷酸环化酶是G蛋白偶统中的效应物。