Anti-ADAM19抗体This gene encodes a member of the ADAM （a disintegrin and metalloprotease domain） family.

产品编号 yb-5850R
英文名称 Anti-ADAM19抗体
中文名称 去整合素样金属蛋白酶19抗体
别    名 A disintegrin and metalloproteinase domain 19 (meltrin beta); A disintegrin and metalloproteinase domain 19; ADAM 19; ADAM metallopeptidase domain 19; Disintegrin and metalloproteinase domain containing protein 19; FKSG 34; FKSG34; MADDAM; Meltrin beta; ADA19_HUMAN; Metalloprotease and disintegrin dentritic antigen marker; MLTN B; MLTNB.
 Anti-ADAM19抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  信号转导  细胞骨架  细胞外基质  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADAM19
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013].

Function:
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). 

Subunit:
Interacts with SH3PXD2A.

Subcellular Location:
Membrane; Single-pass type I membrane protein. 

Tissue Specificity:
Expressed in many normal organ tissues and several cancer cell lines. 

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity). 

Similarity:
Contains 1 disintegrin domain.
Contains 1 EGF-like domain.
Contains 1 peptidase M12B domain.

Database links:

Entrez Gene: 8728 Human

Entrez Gene: 11492 Mouse

Entrez Gene: 303068 Rat

Omim: 603640 Human

SwissProt: Q9H013 Human

SwissProt: O35674 Mouse

SwissProt: Q14BL7 Mouse

SwissProt: Q80UF6 Mouse

Unigene: 89940 Mouse

 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.