Anti-AANKS1A抗体May play a negative role in growth factor receptor signaling pathways.

产品编号 yb-7966R
英文名称 Anti-AANKS1A抗体
中文名称 锚蛋白重复及SAM结构域蛋白1A抗体
别    名 ANKS 1; ANKS 1A; ANKS1; ANKS1A; Ankyrin repeat and SAM domain containing 1; Ankyrin repeat and SAM domain containing protein 1A; Ankyrin repeat and SAM domain-containing protein 1A; Ankyrin repeat and sterile alpha motif domain containing 1A; ANS1A_HUMAN; KIAA0229; MGC42354; Odin.
Anti-AANKS1A抗体
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ANKS1A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
May play a negative role in growth factor receptor signaling pathways.

Function:
Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.

Subunit:
Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination.

Subcellular Location:
Cytoplasm. Cell projection. Note=Cytoplasmic before and after growth factor treatment. 

Tissue Specificity:
Widely expressed (at protein level). 

Post-translational modifications:
Phosphorylated on tyrosine residues in response to EGF and PDGF.

Similarity:
Contains 6 ANK repeats. 
Contains 1 PID domain. 
Contains 2 SAM (sterile alpha motif) domains. 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.