Anti-AGFG1抗体Required for vesicle docking or fusion during acrosome biogenesis （By similarity）. May play a role in RNA trafficking or localization.

产品编号 yb-8072R
英文名称 Anti-AGFG1抗体
中文名称 艾滋病病毒复制结合蛋白抗体
别    名 HIV 1 Rev binding protein; RAB; Rev/Rex activation domain-binding protein; RIP; AGFG1; AGFG1_HUMAN; Arf-GAP domain and FG repeats-containing protein 1; ArfGAP with FG repeats 1; HIV-1 Rev-binding protein; HRB; Nucleoporin like protein RIP; Nucleoporin-like protein RIP; Rev interacting protein; Rev-interacting protein.
Anti-AGFG1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  信号转导  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AGFG1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.

Function:
Required for vesicle docking or fusion during acrosomebiogenesis (By similarity). May play a role in RNA trafficking orlocalization. In case of infection by HIV-1, acts as a cofactor forviral Rev and promotes movement of Rev-responsiveelement-containing RNAs from the nuclear periphery to thecytoplasm. This step is essential for HIV-1 replication. 

Subunit:
Interacts with EPS15R and EPS15. Interacts with FCHO1.

Subcellular Location:
Nucleus. Cytoplasmic vesicle.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
O-glycosylated (By similarity). 

Similarity:
Contains 1 Arf-GAP domain.

Database links:
UniProtKB/Swiss-Prot: P52594.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.