Anti-ALS2CR3抗体ALS2CR3 may regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

产品编号 yb-11650R
英文名称 Anti-ALS2CR3抗体
中文名称 肌萎缩侧索硬化症相关蛋白3抗体
别    名 ALS2CR3; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein;TRAK2_HUMAN; Trafficking kinesin-binding protein 2.
 Anti-ALS2CR3抗体   
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  神经生物学  Alzheimer's  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 101kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ALS2CR3 (701-800aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
ALS2CR3 may regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Function:
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR 

Subunit:
Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

Subcellular Location:
Cytoplasm (By similarity). Early endosome (By similarity). Mitochondrion (By similarity). Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner

Tissue Specificity:
Widely expressed, with highest expression in heart.

Post-translational modifications:
O-glycosylated

Similarity:
Contains 1 HAP1 N-terminal domain.

Database links:
UniProtKB/Swiss-Prot: O60296.2
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.