Anti-CLUAP1抗体CLUAP1 （Clusterin associated protein 1） is a 413 amino acid nuclear protein that exists as two alternatively spliced isoforms that interact with Clusterin.

产品编号 yb-6805R
英文名称 Anti-CLUAP1抗体
中文名称 成簇相关蛋白1抗体
别    名 Clusterin associated protein 1; FLJ13297; KIAA0643; CLUA1_HUMAN.
 Anti-CLUAP1抗体 
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CLUAP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
CLUAP1 (Clusterin associated protein 1) is a 413 amino acid nuclear protein that exists as two alternatively spliced isoforms that interact with Clusterin. CLUAP1 is suggested to play a role in apoptosis and cell proliferation, and is expressed in testis, thrachea and thyroid, with low levels found in adrenal gland and spinal cord. The gene encoding CLUAP1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Function:
May play a role in cell proliferation or apoptosis. 

Subunit:
Interacts with CLU/clusterin. 

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. 

Database links:
UniProtKB/Swiss-Prot: Q96AJ1.4
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.