Anti-Calpain 12抗体Calpains are a family of cytosolic calcium activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin and cyto

产品编号 yb-6798R
英文名称 Anti-Calpain 12抗体
中文名称 钙激活蛋白酶12抗体
别    名 Calpain12; Calpain-12; CAPN 12; CAPN12; EC 3.4.22.; MGC20576; CAN12_HUMAN.
Anti-Calpain 12抗体 
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calpain 12
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Calpains are a family of cytosolic calcium activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin and cytoskeletal interactions, and synaptic plasticity. Calpain 12 was first described in the mouse, most strongly in the skin, and maps to mouse chromosome 7. Isoforms differ in the carboxyterminal ends, ending with aberrant domain III and lacking domain IV. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV, making Calpain 12 most similar to calpains 1 and 2.

Function:
Calcium-regulated non-lysosomal thiol-protease (By similarity). 

Similarity:
Belongs to the peptidase C2 family.
Contains 1 calpain catalytic domain. 
Contains 1 EF-hand domain.

Database links:
UniProtKB/Swiss-Prot: Q6ZSI9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.