Anti-ccnb1ip1抗体E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosi

产品编号 yb-7784R
英文名称 Anti-ccnb1ip1抗体
中文名称 周期蛋白B1结合蛋白1抗体
别    名 C14orf18; CCNB1IP1; Chromosome 14 open reading frame 18; CIP1_HUMAN; Cyclin B1 interacting protein 1; Cyclin-B1-interacting protein 1; E3 ubiquitin-protein ligase CCNB1IP1; Enhancer of invasion 10; HEI10; Human enhancer of invasion 10.
Anti-ccnb1ip1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  细胞周期蛋白  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ccnb1ip1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.

Function:
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. 

Subunit:
Binds CCNB1 and UBE2L3. 

Subcellular Location:
Nucleus. Chromosome. Note=May associate with segregating chromosomes during metaphase and anaphase. 

Tissue Specificity:
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.

Post-translational modifications:
Ubiquitinated; autoubiquitinated. 
Phosphorylated by CDK1 on serine or threonine residues (in vitro). 

Similarity:
Contains 1 RING-type zinc finger. 

Database links:
UniProtKB/Swiss-Prot: Q9NPC3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.