Anti-CCNDBP1抗体May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex,

产品编号 yb-7885R
英文名称 Anti-CCNDBP1抗体
中文名称 周期素D结合蛋白1抗体
别    名 Maternal inhibition of differentiation; SECC 8; SSEC 8; CCDB1_HUMAN; CCNDBP 1; Ccndbp1; Cyclin D type binding protein 1; Cyclin-D1-binding protein 1; D type cyclin interacting protein 1; DIP 1; DIP1; GCIP; Grap 2 and cyclin D interacting protein; Grap 2 cyclin D interacting protein GCIP; Grap 2 cyclin interacting protein; Grap2 and cyclin D interacting protein; Grap2 and cyclin-D-interacting protein; Grap2 cyclin D interacting protein GCIP; Grap2 cyclin interacting protein; HHM protein; Human homolog of Maid; MAID; MAID protein; Stage specific embryonic cDNA 8.
Anti-CCNDBP1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  细胞周期蛋白  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCNDBP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

Function:
May negatively regulate cell cycle progression. May actat least in part via inhibition of the cyclin-D1/CDK4 complex,thereby preventing phosphorylation of RB1 and blockingE2F-dependent transcription.

Subunit:
Interacts with CCND1 and GRAP2. May also interact withCOPS5, RPLP0, SIRT6, SYF2 and TCF3. 

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Ubiquitously expressed. Expression isdown-regulated in a variety of tumor types including breast, colon,prostate and rectal tumors, and is up-regulated in certain hepaticcarcinomas.

Post-translational modifications:
Phosphorylated.

Similarity:
Belongs to the CCNDBP1 family. 

Database links:
UniProtKB/Swiss-Prot: O95273.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.