Anti-CPB2CEACAM16抗体The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear.

产品编号 yb-7998R
英文名称 Anti-CPB2CEACAM16抗体
中文名称 癌胚抗原相关细胞粘附分子16抗体
别    名 Carcinoembryonic antigen like 2; Carcinoembryonic antigen like 2 protein; Carcinoembryonic antigen related cell adhesion molecule 16; CEAL2; CEA16_HUMAN.
Anti-CPB2CEACAM16抗体 
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from hu CEACAM16/CEAL2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]. 

Function:
May play a role in maintaining the integrity of the tectorial membrane. 

Subunit:
Monomer. Homodimer. Tetramer. Interacts with TECTA.

Subcellular Location:
Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane (By similarity).

DISEASE:
Defects in CEACAM16 are the cause of deafness autosomal dominant type 4B (DFNA4B) [MIM:614614]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 

Similarity:
Belongs to the immunoglobulin superfamily. CEA family. 
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 

Database links:
UniProtKB/Swiss-Prot: Q2WEN9.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.