Anti-CHRNA3抗体Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters.

产品编号 yb-6455R
英文名称 Anti-CHRNA3抗体
中文名称 烟碱型乙酰*受体α3抗体
别    名 Nicotinic Acetylcholine Receptor alpha 3; ACHA3_HUMAN; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypeptide 3; CHRNA 3; CHRNA3; CHRNA-3; NACHRA 3; NACHRA3; Neuronal acetylcholine receptor protein alpha 3 chain precursor; Neuronal acetylcholine receptor subunit alpha 3; Neuronal acetylcholine receptor subunit alpha-3; Neuronal nicotinic acetylcholine receptor alpha 3 subunit.
Anti-CHRNA3抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  神经生物学  信号转导  通道蛋白  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHRNA3/AChRα3 (111-160aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
产品介绍 background:
Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChR?, also known as LNCR2, PAOD2, NACHRA3 or CHRNA3, is a 505 amino acid multi-pass membrane protein that belongs to the ligand-gated ion channel receptor family and may play a role in neurotransmission. 

Function:
After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane.

Subunit:
Neuronal AChR is composed of two different types ofsubunits: alpha and beta. Alpha-3 subunit can be combined to beta-2or beta-4 to give rise to functional receptors. Interacts withRIC3; which is required for proper folding and assembly.

Subcellular Location:
Cell junction, synapse, postsynaptic cellmembrane; Multi-pass membrane protein. Cell membrane; Multi-passmembrane protein.

Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9)family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Alpha-3/CHRNA3 sub-subfamily.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.