Anti-COPS7A抗体C3orf39, also known as AGO61, is a 580 amino acid secreted protein belonging to the glycosyltransferase 61 family.

产品编号 yb-9830R
英文名称 Anti-COPS7A抗体
中文名称 3号染色体开放阅读框39抗体
别    名 AGO61; Chromosome 3 open reading frame 39; FLJ14566; Uncharacterized glycosyltransferase AGO61 precursor; GTDC2_HUMAN.
Anti-COPS7A抗体    
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
细胞定位 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human C3orf39
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-COPS7A抗体
PubMed PubMed
产品介绍 background:
C3orf39, also known as AGO61, is a 580 amino acid secreted protein belonging to the glycosyltransferase 61 family. C3orf39 is encoded by a gene that maps to human chromosome 3p25.1. Chromosome 3 is made up of approximay 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.

Subcellular Location:
Secreted (Potential). 

Tissue Specificity:
Highly expressed in the brain, muscle, heart, and kidney in both fetus and adult. In the brain, highest expression in the cortex and cerebellum. Highly expressed in the pancreas. 

DISEASE:
Defects in GTDC2 are the cause of muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A8 (MDDGA8) [MIM:614830]. An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye-brain disease. 

Similarity:
Belongs to the glycosyltransferase 61 family. 

Anti-COPS7A抗体
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.