Anti-C19orf46抗体C19orf46 is a 404 amino acid single-pass type IV membrane protein that belongs to the nesprin family.

产品编号 yb-9682R
英文名称 Anti-C19orf46抗体
中文名称 突触核膜蛋白4抗体
别    名 Nesprin-4; Nesprin4; Nesprin 4; Chromosome 19 open reading frame 46; FLJ36445; Hypothetical protein LOC163183; SYNE4_HUMAN.
 Anti-C19orf46抗体
说 明 书 0.1ml  0.2ml  
研究领域 心血管  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
细胞定位 细胞核 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human C19orf46
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
C19orf46 is a 404 amino acid single-pass type IV membrane protein that belongs to the nesprin family. C19orf46 partcipates in the establishment of secretory epithelial morphology by inducing kinesin-dependent apical migration of the centrosome and Golgi apparatus as well as basal localization of the nucleus. C19orf46 interacts with UKHC and KCL1, and exists as two alternatively spliced isoforms. C19orf46 contains a KASH domain, which consists of a transmembrane motif, mediates nuclear enevelop targeting and binds to the SUN domain of SUN1 and SUN2. C19orf46 is encoded by a gene located on human chromosome 19, which consists of approximay 63 million bases and makes up over 2% of human genomic DNA.

Function:
Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). 

Subunit:
Interacts with KIF5B and KCL1.

Subcellular Location:
Nucleus membrane; Single-pass type IV membrane protein

Similarity:
Belongs to the nesprin family. 
Contains 1 KASH domain. 

 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.