Anti-C4orf14抗体Representing approximay 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene,

产品编号 yb-9992R
英文名称 Anti-C4orf14抗体
中文名称 4号染色体开放阅读框14抗体
别    名 mAt; Chromosome 4 open reading frame 14; hAt; Hypothetical protein LOC84273; MGC3232; Putative ortholog of Arabidopsis mitochondrial nitric oxide synthase; Uncharacterized protein C4orf14; _HUMAN.
Anti-C4orf14抗体 
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  发育生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human C4orf14
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Representing approximay 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes. The C4orf14 gene product has been provisionally designated C4orf14 pending further characterization.

Function:
Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. 

Subunit:
Homodimer or multimer (By similarity). Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27. 

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.