Anti-CyCyclin M3抗体Cyclin M3 is a 707 amino acid multi-pass membrane protein that shares weak sequence similarity with cyclin proteins,

产品编号 yb-12045R
英文名称 Anti-CyCyclin M3抗体
中文名称 周期素M3抗体
别    名 ACDP3; Ancient conserved domain containing protein 3; CNNM3; DKFZp434I1016; FLJ20018; Metal transporter CNNM3; CNNM3_HUMAN.
Anti-CyCyclin M3抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  信号转导  细胞周期蛋白  通道蛋白  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin M3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Cyclin M3 is a 707 amino acid multi-pass membrane protein that shares weak sequence similarity with cyclin proteins, yet displays no cyclin-like function in vivo. Though ubiquitously expressed, Cyclin M3 is found at highest levels in kidney, brain, spleen and heart. Cyclin M3 is localized to the nucleus where it is likely a metal transporter. Cyclin M3 contains two CBS domains, which appear to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet and may play a regulatory role in sensitizing proteins to adenosyl-carrying ligands. There are three isoforms of Cyclin M3 that are produced as a result of alternative splicing events.

Function:
Cyclin M3 is a probable metal transporter. There are three named isoforms.

Subcellular Location:
Integral to plasma membrane; Multi-pass membrane protein

Tissue Specificity:
Widely expressed. Expressed at higher level in heart and spleen.

Similarity:
Belongs to the ACDP family. 
Contains 2 CBS domains. 
Contains 1 DUF21 domain.

Database links:
UniProtKB/Swiss-Prot: Q8NE01.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.