Anti-CHCHD7抗体CHCHD7 is an 85 amino acid protein that contains one CHCH domain. A chromosomal translocation involving the CHCHD7 gene and PLAG1

产品编号 yb-13889R
英文名称 Anti-CHCHD7抗体
中文名称 卷曲螺旋结构域蛋白CHCHD7抗体
别    名 Coiled coil helix coiled coil helix domain containing 7; Coiled coil helix coiled coil helix domain containing protein 7; COX23; CHCH7_HUMAN; COX23 cytochrome c oxidase assembly homolog.
Anti-CHCHD7抗体 
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHCHD7
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CHCHD7 is an 85 amino acid protein that contains one CHCH domain. A chromosomal translocation involving the CHCHD7 gene and PLAG1 gene is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. There are three isoforms of CHCHD7 that are produced as a result of alternative splicing events. The gene encoding CHCHD7 maps to human chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects.

Subunit:
Monomer.

Subcellular Location:
Mitochondrion intermembrane space 

DISEASE:
Note=A chromosomal aberration involving CHCHD7 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(6;8)(p21.3-22;q13) with PLAG1.

Similarity:
Belongs to the CHCHD7 family.
Contains 1 CHCH domain.