Anti-CTC1抗体This gene encodes a component of the CST complex. This complex plays an essential role in protecting omeres from degradation. This protein also forms

产品编号 yb-14097R
英文名称 Anti-CTC1抗体
中文名称 7号染色体开放阅读框68抗体
别    名 CTC1; C17orf68; Conserved omere maintenance component 1; CST complex subunit CTC1; CTC1; CTC1_HUMAN; HBV DNAPTP1-transactivated protein B.
Anti-CTC1抗体
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 135kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTC1/C17orf68
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4
PubMed PubMed
产品介绍 background:
This gene encodes a component of the CST complex. This complex plays an essential role in protecting omeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

Function:
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect omeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to omere protection, the CST complex has probably a more general role in DNA metabolism at non-omeric sites.

Subcellular Location:
Nucleus. Chromosome > omere. A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the omeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.

DISEASE:
Cerebroretinal microangiopathy with calcifications and cysts