Anti-CDRAK1抗体DRAK1 （DAP kinase-related apoptosis-inducing protein kinase 1） is a novel member of the ser/thr protein kinase family,

产品编号yb-6770R
英文名称 Anti-CDRAK1抗体
中文名称 */*蛋白激酶17A/DAP凋亡诱导蛋白激酶1抗体
别    名 DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; EC 2.7.11.1; Serine / threonine kinase 17a death associated protein kinase related 1; Serine/threonine kinase 17a; Serine/threonine protein kinase 17a; STK17 A; STK17A; ST17A_HUMAN.
 Anti-CDRAK1抗体 
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  细胞凋亡  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DRAK1/STK17A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) is a novel member of the ser/thr protein kinase family, which mediate apoptosis through their catalytic activities. The full-length cDNA encodes a deduced 414-amino acid protein with a molecular mass of 46.56 kD. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. DRAK1 messenger RNA appears to be ubiquitously expressed in human tissues. Overexpression of DRAK1 induces apoptosis. It has been shown in vitro that DRAK1 is capable of autophosphorylation and of phosphorylating the myosin light chain as an exogenous substrate, and that the noncatalytic C terminus is crucial for full kinase activity.

Function:
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Contains 1 protein kinase domain.
 
Database links:

Entrez Gene: 420775 Chicken

Entrez Gene: 9263 Human

Entrez Gene: 100008622 Rabbit