Anti-DDPP8抗体Dipeptidyl peptidases （DPPs） mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes,

产品编号 yb-8295R
英文名称Anti-DDPP8抗体
中文名称 二肽基肽酶8抗体
别    名 Dipeptidyl peptidase 8; Dipeptidyl peptidase IV-related protein 1; Dipeptidyl peptidase VIII; DP8; DPRP-1; EC 3.4.14.5; Prolyl dipeptidase DPP8; DPP8_HUMAN.
Anti-DDPP8抗体 
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  发育生物学  信号转导  糖尿病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DPP8/DPRP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPRP1 (dipeptidyl-peptidase IV-related protein 1), also known as DPP8 (dipeptidyl-peptidase 8), DP8 or MSTP141, is a member of the peptidase S9B family of proteins that exhibit prolyl oligopeptidase activity. DPRP1 localizes to the cytoplasm and is ubiquitously expressed with predominant expression in placenta, brain, prostate, testis and muscle. DPRP1 is similar to CD26 (dipeptidyl peptidase IV) suggesting that it may be involved in immune function and participate in the activation of T-cells.

Function:
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. 

Subcellular Location:
Cytoplasmic

Tissue Specificity:
predominant expression in placenta, brain, prostate, testis and muscle.

Similarity:
Belongs to the peptidase S9B family. DPPIV subfamily. 

Database links:
UniProtKB/Swiss-Prot: Q6V1X1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.