Anti-DCHS1抗体The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical

产品编号 yb-6999R
英文名称 Anti-DCHS1抗体
中文名称 原钙粘蛋白16抗体
别    名 Protein dachsous homolog 1; Cadherin-19; dachsous; Cadherin 19; Cadherin-25; CDH19; CDH25; DCHS1; FIB1; Fibroblast cadherin-1; PCD16_HUMAN; PCDH16; Protocadherin-16; 3110041P15Rik; C130033F22Rik; dachsous 1 (Drosophila); KIAA1773; OTTMUSP00000015964; Protein dachsous homolog 1Protocadherin-16.
 Anti-DCHS1抗体    
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  转录调节因子  结合蛋白  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 342kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cadherin 19
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. DCHS1 (dachsous 1), also known as CDH19, CDH25, FIB1, KIAA1773 or PCDH16, is a 3,298 amino acid single-pass type I membrane protein that contains 27 cadherin domains and belongs to the cadherin superfamily. Expressed specifically in fibroblasts, DCHS1 functions as a Ca2+-dependent cell-cell (specifically fibroblast-fibroblast) adhesion protein that may be involved in wound healing. The gene encoding DCHS1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. 

Subcellular Location:
Cell membrane.

Tissue Specificity:
Fibroblast specific.

Similarity:
Contains 27 cadherin domains.
 
Database links: