Anti-DIXDC1抗体The protein encoded by this gene is a positive regulator of the Wnt signaling pathway.

产品编号 yb-14334R
英文名称 Anti-DIXDC1抗体
中文名称 卷曲螺旋蛋白DIX1抗体
别    名 CCD1; Ccd1Aalpha1L; Ccd1Abeta1L; Ccd1BalphaL; Ccd1BbetaL; Ccd1CL; Coiled coil DIX1; Coiled coil protein DIX1; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain containing 1; DIX domain containing protein 1; DIX domain-containing protein 1; DIXC1_HUMAN; DIXDC1; Dixin; KIAA1735.
 Anti-DIXDC1抗体  
说 明 书 0.1ml  0.2ml  
研究领域 心血管  细胞生物  信号转导  干细胞  激酶和磷酸酶  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DIXDC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Function:
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.

Subcellular Location:
Cytoplasm; Cell junction; focal adhesion. Associated with actin stress fiber at the filament ends and Cytoplasm; cytosol. Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis.

Tissue Specificity:
Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
 
Post-translational modifications:
Phosphorylated on tyrosine and serine residues. Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increase