Anti-DNAJC1抗体The DnaJ family comprises a group of chaperone proteins that contain a J domain and have diverse cellular

产品编号 yb-14377R
英文名称 Anti-DNAJC1抗体
中文名称 DNAJC1蛋白抗体
别    名 DnaJ (Hsp40) homolog subfamily C member 1; DnaJ homolog subfamily C member 1; DnaJ like protein; DnaJ protein homolog MTJ1; Dnajc1; DNAJL1; DNJC1_HUMAN; ERdj1; HTJ1; MGC131954; MTJ1.
 Anti-DNAJC1抗体 
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNAJC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
The DnaJ family comprises a group of chaperone proteins that contain a J domain and have diverse cellular localization and functions. DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis and are also important mediators of proteolysis and protein degradation. DnaJC1 (DnaJ homolog subfamily C member 1), also designated MTJ1, HTJ1, ERdj1 or DNAJL1, is a 554 amino acid single-pass type I membrane protein found in the membrane of the endoplasmic reticulum, nucleus and microsome. DnaJC1 contains one J domain and two SANT domains, through which it interacts with GRP 78 and AACT, respectively. Via its cytosolic domain, DnaJC1 interacts with ribosomes and likely modulates protein synthesis. The gene encoding DnaJC1 maps to human chromosome 10p12.31 and mouse chromosome 2 A3.

Function:
May modulate protein synthesis.
 
Subcellular Location:
Endoplasmic reticulum membrane. Nucleus membrane. Microsome membrane.