Anti-DOCK10抗体DOCK 10 is a 2,183 amino acid protein that belongs to the DOCK family of cytokinesis-regulating proteins

产品编号 yb-14403R
英文名称 Anti-DOCK10抗体
中文名称 DOCK10蛋白抗体
别    名 9330153B10Rik; A630054M16Rik; dedicator of cytokinesis 10; Dedicator of cytokinesis protein 10; DKFZp781A1532; DRIP2; Jr4; Jr5; KIAA0694; MGC183664; mKIAA0694; Nbla10300; R75174; ZIZ3; Zizimin 3.
Anti-DOCK10抗体
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 250kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DOCK10
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
产品介绍 background:
DOCK 10 is a 2,183 amino acid protein that belongs to the DOCK family of cytokinesis-regulating proteins and cotnains one PH domain, one DHR-1 domain and one DHR-2 domain. Expressed at lower levels in lung and brain tissue, DOCK 10 functions as a potential GEF (guanine nucleotide exchange factor) that is able to activate target GTPases by exchanging bound GDP for free GTP. Multiple isoforms of DOCK 10 exist due to alternative splicing events. The gene encoding DOCK 10 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alstr鰉 syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.

Function:
DOCK10 is a potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Two named isoforms exist, produced by alternative splicing.