Anti-ESAT6抗体Mycobacterium tuberculosis is a slow-growing obligate aerobic bacillus that causes most cases of tuberculosis （TB）.

产品编号 yb-13107R
英文名称 Anti-ESAT6抗体
中文名称 结核分枝杆菌分泌性蛋白ESAT6抗体
别    名 6 kDa early secretory antigenic target; 6 kDa early secretory antigenic target ESXA; ESAT 6; esaT6; ESXA; ESXA_MYCTU; ESAT-6.
Anti-ESAT6抗体  
说 明 书 0.2ml  
研究领域 细胞生物  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mycobacterium tuberculosis, Mycobacterium szulgai, Mycobacterium kansasii, Mycobacterium riyadhense, Mycobacterium ulcerans, Mycobacterium marinum
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10kDa
细胞定位 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Mycobacterium tuberculosis ESAT6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Mycobacterium tuberculosis is a slow-growing obligate aerobic bacillus that causes most cases of tuberculosis (TB). It is a small, rod-like microbe that can withstand weak disinfectants and survive in a dry state for weeks, but can only grow within a host organism. M. tuberculosis has a thick waxy cell wall that is responsible for the typical caseous granuloma formation in tuberculosis. ESAT6 is a protein secreted by M. tuberculosis that induces a strong immune response in infected organisms, making it a strong candidate for the development of a vaccine against tuberculosis. ESAT6 may also be useful in the detection of the disease. Deletion of the ESAT6 gene leads to the loss of virulence of M. tuberculosis.

Function:
The ESAT6 antigen from Mycobacterium tuberculosis is a dominant target for cell mediated immunity in the early phase of tuberculosis (TB) in TB patients as well as in various animal models. ESAT6 is not found in M. bovis BCG. Its function is not known but it elicits high level of IFN-gamma from memory effector cells during the first phase of a protective immune response. 

Subcellular Location:
Secreted

Similarity:
Belongs to the ESAT-6 (esx) family.

Database links:
UniProtKB/Swiss-Prot: P0A564.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.