Anti-EXOC8抗体Exocytosis is crucial in membrane trafficking and it mediates hormone and neurotransmitter secretion out of the cell,

产品编号 yb-14665R
英文名称 Anti-EXOC8抗体
中文名称 EXOC8蛋白抗体
别    名 EXO84; Exo84p; exoc8; EXOC8_HUMAN; Exocyst complex 84 kDa subunit; Exocyst complex component 8; SEC84.
Anti-EXOC8抗体
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EXOC8
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Exocytosis is crucial in membrane trafficking and it mediates hormone and neurotransmitter secretion out of the cell, as well as the incorporation of membrane proteins and lipids to the plasma membrane. It is crucial for cell-cell communication, cell growth and cell polarity. The exocyst complex is a multi-protein complex that consists of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, and is essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. The exocyst complex inhibits tubulin polymerization in vitro, suggesting that the exocyst complex is important for modulating the microtubule dynamics that underlie exocytosis. Exo84 (Exocyst complex 84 kDa subunit), also known as Exocyst complex component 8, is a 725 amino acid protein that is one of eight protein subunits composing the mammalian exocyst complex. Both Exo84 and Sec5 are effector targets for active Ral GTPases, which are responsible for regulating exocyst complex activities.

Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Subcellular Location:
Cytoplasm. Cell projection > growth cone. Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol-3,4,5-trisphosphate groups.

Similarity:
Belongs to the EXO84 family.
Contains 1 PH domain.