Anti-CD1a抗体This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex （MHC） proteins and form heterodimers with

产品编号 byb-3786R
英文名称 Anti-CD1a抗体
中文名称 T淋巴细胞CD1抗体
别    名 CD1D; A1 domain; CD1A; CD1A antigen; CD1B; CD1b antigen; CD1b molecule; CD1C; CD1C antigen; CD1c molecule; CD1d molecule; Cd1d1; Cortical thymocyte antigen CD1A; Cortical thymocyte antigen CD1B; Cortical thymocyte antigen CD1C; Cortical thymocyte antigen CD1D; hTa1 thymocyte antigenLy38; Ly38; T cell surface glycoprotein CD1a; T cell surface glycoprotein CD1b; T cell surface glycoprotein CD1c; T cell surface glycoprotein CD1d; T6/Leu6.
Anti-CD1a抗体  
说 明 书 0.1ml  0.2ml  
研究领域 免疫学  细胞表面分子  t-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞浆 细胞膜 细胞外基质 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD1a
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq].

Function:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Subcellular Location:
Cell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.

Tissue Specificity:
Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

Similarity:
Contains 1 Ig-like (immunoglobulin-like) domain.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.