Anti-CD168抗体是透明质酸的受体之一,该蛋白与恶性肿瘤生成、浸润和转移有密切关联。其表达水平升高与肿瘤的侵袭呈正相关,是衡量肿瘤侵袭程度的重要标志。主要定位于细胞浆。

产品编号yb-3845R
英文名称 Anti-CD168抗体
中文名称 透明质酸介导细胞游走受体抗体
别    名 CD168; CD168 antigen; HMMR; HMMR_HUMAN; Hyaluronan mediated motility receptor; Hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; Intracellular hyaluronic acid-binding protein; MGC119494; MGC119495; Receptor for hyaluronan-mediated motility; RHAMM; Hyaluronan mediated motility receptor
 Anti-CD168抗体    
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  细胞膜受体  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82-84kDa
细胞定位 细胞浆 细胞膜 细胞外基质 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RHAMM C-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
The CD168 antigen is a non-integral cell surface hyaluronan receptor and intracellular protein. When hyaluronan binds to CD168, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. CD168 activation regulates various cellular processes including cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis, and metastasis via both extracellular and intracellular pathways. CD168 is involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. CD168 is also a subunit of the HARC complex. CD168 knockdown in human embryonic stem cells results in downregulation of several pluripotency markers, induction of early extraembryonic lineages, loss of cell viability, and changes in cell cycle. 

Function:
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

Subcellular Location:
Cell surface. Cytoplasm.

Tissue Specificity:
Expressed in breast cancer cell lines and in normal breast tissue.

 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

CD168是透明质酸的受体之一,该蛋白与恶性肿瘤生成、浸润和转移有密切关联。其表达水平升高与肿瘤的侵袭呈正相关,是衡量肿瘤侵袭程度的重要标志。主要定位于细胞浆。