Anti-CDKN2D/p19 INK4d抗体The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors.

产品编号 yb-5982R
英文名称 Anti-CDKN2D/p19 INK4d抗体
中文名称 细胞周期蛋白依赖性激酶抑制剂2D抗体
别    名 CDK inhibitor p19INK4d; CDKN2D; cell cycle inhibitor, Nur77 associating protein; Cyclin dependent kinase inhibitor 2D; Cyclin-dependent kinase 4 inhibitor D; Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d; INK4D; p19; p19-INK4D; p19INK4d; Similar to cyclin-dependent kinase inhibitor 2D; CDN2D_HUMAN.
Anti-CDKN2D/p19 INK4d抗体 
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  细胞周期蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDKN2D/p19 INK4d
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]. 

Function:
Interacts strongly with CDK4 and CDK6 and inhibits them. 

Subunit:
Interacts with CDK6. 

Subcellular Location:
Nucleus. Cytoplasm. 

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats. 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.