Anti-CAMTA1抗体CAMTA1 is a transcription activator which is a putatuove tumor suppressor. It is thought to interact with calmodulin.

产品编号 1680-5995R
英文名称 Anti-CAMTA1抗体
中文名称 钙调蛋白结合转录激活因子1抗体
别    名 Calmodulin-binding transcription activator 1; Calmodulin binding transcription activator 1; CMTA1; KIAA0833; CMTA1_HUMAN.
 Anti-CAMTA1抗体  
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 183kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CAMTA1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
CAMTA1 is a transcription activator which is a putatuove tumor suppressor. It is thought to interact with calmodulin. Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.

Function:
Transcriptional activator. May act as a tumor suppressor. 

Subunit:
May interact with calmodulin (Potential). 

Subcellular Location:
Nucleus (Probable). Cytoplasm. 

Tissue Specificity:
Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney. 

Similarity:
Belongs to the CAMTA family.
Contains 3 ANK repeats. 
Contains 1 CG-1 DNA-binding domain. 
Contains 1 IPT/TIG domain. 
Contains 3 IQ domains.

Database links:
UniProtKB/Swiss-Prot: Q9Y6Y1.4
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.