Anti-CADM3抗体Immunoglobulin superfamily member 4B （Cell adhesion molecule 3, Nectin-like protein 1） is a nectin family gene product that contains 2 Ig-like C2-type

产品编号 1680-6027R
英文名称 Anti-CADM3抗体
中文名称 细胞粘附分子3抗体
别    名 Brain immunoglobulin receptor; Synaptic cell adhesion molecule 3; Necl 1; synCAM3; CADM 3; Cell adhesion molecule 3; FLJ10698; IGSF4B; Immunoglobulin superfamily member 4B; NECL1; Nectin like protein 1; TSLC1 like protein 1; TSLL1; CADM3_HUMAN.
 Anti-CADM3抗体  
说 明 书 0.2ml  
研究领域 神经生物学  细胞粘附分子  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CADM3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
Immunoglobulin superfamily member 4B (Cell adhesion molecule 3, Nectin-like protein 1) is a nectin family gene product that contains 2 Ig-like C2-type (immunoglobulin-like) domains and an Ig-like V-type (immunoglobulin-like) domain. IGSF4B is a single-pass type I membrane protein that localizes to cell-cell interacting sites along the plasma membrane. IGSF4B functions as a cell adhesion molecule at cell-cell junctions. IGSF4B can be found as a homodimer and has a dual calcium-independent adhesion function; a homophilic cell-cell interaction and a heterophilic cell-cell interaction involving IGSF4, Nectin 1 and Nectin 3. IGSF4B may also interact with EPB41L1 which has a potential for regulating structure or function of cell-cell junctions By similarity. Isoform 1 is expressed in adult and fetal brain. Isoform 2 is highly expressed in the cerebellum but is also weakly expressed in placenta. IGSF4B has been found to be markedly over-expressed in glioma cell lines and prostate cancer cell lines.

Function:
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.

Subunit:
Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.

Subcellular Location:
Cell junction. Cell membrane. Localized at the cell-cell attached sites of the plasma membrane.

Tissue Specificity:
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.


 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.