Anti-CRABP2抗体A number of specific carrier proteins for members of the vitamin A family have been discovered.

产品编号 yb-6038R
英文名称 Anti-CRABP2抗体
中文名称 细胞维甲酸结合蛋白2抗体
别    名 Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II; CRABP II; CRABPII; CRABP 2; CRABP-2; RBP6; RABP2_HUMAN.
Anti-CRABP2抗体  
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  染色质和核信号  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRABP2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.

Function:
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

Subunit:
Interacts with RXR and RARA. Interacts with importin alpha.

Subcellular Location:
Cytoplasm. Endoplasmic reticulum. Nucleus.

Post-translational modifications:
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.

Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.