Anti-DRIP5抗体The gene encodes a protein that is part of a complex involved in omere length regulation. Pseudogenes are present on chromosomes 5 and 22.

产品编号yb-8677R
英文名称 Anti-DRIP5抗体
中文名称 多巴胺受体相互作用蛋白5抗体
别    名 Dopamine receptor interacting protein 5; Dopamine receptor-interacting protein 5; DRIP 5; DRIP5; hRap1; MGC105533; RAP 1; RAP1 homolog; RAP1, yeast, homolog of antibody Repressor/activator protein 1 homolog antibody TE2IP_HUMAN; omeric Repeat Binding Factor 2 Interacting Protein; omeric repeat-binding factor 2-interacting protein 1; TERF2-interacting protein; TERF2-interacting omeric protein 1; TERF2IP; TRF2 Interacting omeric Protein RAP1; TRF2 interacting omeric RAP1 protein; TRF2-interacting omeric protein 1; TRF2-interacting omeric protein.
 Anti-DRIP5抗体
说 明 书 0.2ml  
研究领域 细胞生物  染色质和核信号  神经生物学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
The gene encodes a protein that is part of a complex involved in omere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]

Function:
Acts both as a regulator of omere function and as a transcription regulator. Involved in the regulation of omere length and protection as a component of the shelterin complex (osome). In contrast to other components of the shelterin complex, it is dispensible for omere capping and does not participate in the protection of omeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate omere recombination and is essential for repressing homology-directed repair (HDR), which can affect omere length. Does not bind DNA directly: recruited to omeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in omeres, also acts as a transcription regulator: recruited to extraomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
 
Subcellular Location:
Cytoplasm. Nucleus. Chromosome > omere. Associates with chromosomes, both at omeres and in extraomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.

Tissue Specificity:
Ubiquitous. Highly expressed.